Structures of Hemoglobin
Primary (1o) structure:
Amino acid sequence
Secondary (2o) structure:
Amino acid chain twists
Tertiary (3o) structure:
Bending and folding of globin chain into pretzel-like shape and heme is added
Quaternary (4o) structure:
Four tertiary structures joined together to form hemoglobin molecule
Sickle cell disease =
Abnormality with primary structure
Thalassemia disease =
Abnormality with quaternary structure