Unit Notes - 4
7. Nutritional elements responsible for megaloblastic erythropoiesis:
Vitamin B12  and folic acid:
Deficiencies in these vitamins result in inhibition of DNA synthesis which causes a “asynchronism” where the cytoplasm matures faster than the nucleus resulting in a larger than normal cell
8. Stages of development in megaloblastic erythropoiesis:
Promegaloblast
Basophilic megaloblast
Polychromatophilic megaloblast
Orthochromic megaloblast
Macrocyte