Notes
Slide Show
Outline
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CLSC260
FUNDAMENTALS OF HUMAN BLOOD BIOLOGY
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Unit Objectives - 1
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Hemoglobin
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Functions of Hemoglobin
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Heme Synthesis
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Synthesis of Heme
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Synthesis of Globin Chains
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Structures of Hemoglobin
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Types of globin chaiins
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Hemoglobin Assembly Facts
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Hemoglobin Synthesis - 1
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Hemoglobin Structure - 2
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Abnormal Hemoglobins
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What am I?
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Iron Absorption – Fe++ or Fe+++
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Oxygen Dissociation Curve
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Shift-to-right
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Shift-to-left
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Oxyhemoglobin
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Deoxyhemoglobin
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Bohr effect - 1
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Bohr effect - 2
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Bohr effect - 3
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Composition of Red Cell Membrane
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Layers of Red Cell Membrane
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Cell Membrane - 1
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Outer Layer
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Central Layer
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Inner Layer
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Sequence of RBC Ageing
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Changes when RBC’s Age
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Types of Hemolysis
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Extravascular Hemolysis
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Bilirubin
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Extravascular Features
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Extravascular - Anemias
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Intravascular Hemolysis
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Intravascular Features
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Intravascular - Anemias
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 End of Unit 05
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Unit Notes - 1
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Unit Notes - 2
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Unit Notes - 3
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Unit Notes - 4
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Macrocytes
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Oval Macrocytes
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Discocytes - Normocytes
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Microcytes
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Spherocytes
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Ovalocytes/elliptocytes
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Stomatocytes
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Drepanocytes
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Hemoglobin C crystal
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Hemoglobin SC crystals
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Leptocytes/Target cells
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Schistocytes
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Helmet cells
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Acanthocytes
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Echinocytes/Burr cells
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Dacryocytes
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Basophilic stippling
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Howell-Jolly bodies
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Heinz bodies
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Bite cells
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Sideroblasts
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Siderocytes
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Cabot rings
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Anisocytosis – variation in size
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Poikilocytosis – variation in shape
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Hypochromasia – decreased color
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Polychromasia – variation in color
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Spherocytes
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Rouleaux