Aspirin Effects
Aspirin and it’s effects on platelet function:
Arachidonic acid
ENDOTHELIAL CELLS
PGG2
CYCLOOXYGENASE
PGI2
Thromboxane A2
Inhibits aggregation
Stimulates aggregation
PLATELETS                
Arachidonic acid
PGG2
Prostaglandin synthetase
Thromboxane synthetase
CYCLOOXYGENASE of platelets is inhibited by low doses
CYCLOOXYGENASE of endothelial cells is inhibited by high doses