Protein
C
Definition:
Protein C is a vitamin K dependent
protein which is activated by thrombomodulin-thrombin complex.
APC can also stimulate fibrinolysis
by causing endothelial cells to release tissue plasminogen activator.
Chromogenic assay where protein C
activator is added to patient plasma and the amount of colored complex formed is directly proportional to
amount of protein C present.
Activated protein C (APC) then
combines with Protein S and this complex will inactivate factors:
Va and VIIIa
Principle of test: