No Slide Title

Multiple Sclerosis - 3

Laboratory findings:

eit is important to determine source of IgG in CSF

Žis it produced in the spinal cord

Žis it produced elsewhere and has crossed the blood- brain barrier

etwo assays used to determine origin of IgG in CSF:

Žoligoclonal banding technique:

~protein electrophoresis of CSF shows multiple bands in the ( region

~protein electrophoresis of serum shows multiple bands in the ( region

~if isoelectric focusing used:

qCSF shows band pattern in ( region

qserum shows no band pattern in ( region