HDN - 2
Mechanism of
disease:
ewoman has been exposed to red blood cell antigens
which are not found on her own red blood cells and her immune
system has responded by producing antigen-specific
antibodies
ethese maternal antigen-specific IgG antibodies
cross the placental barrier and attach to fetal red cells
having the antigen on them
efetal red cells are then lyzed and resulting
bilirubin is handled by maternal liver
eonce the baby is delivered the baby=s liver must
handle the bilirubin
emost frequent antigen-antibodies involved in HDN
are:
A antigen/anti-A antibodies
B antigen/anti-B antibodies
D antigen/anti-D antibodies
other Rh antigens/anti-Rh antibodies
ABO HDN
Rh HDN
