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- Hasimoto=s Thyroiditis
- OSF - 14
- Page 276
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- Mechanism of disease:
- eautoimmune disorder seen most often in women and is leading cause of
thyroiditis (inflammation of thyroid gland).
- ethese autoantibodies are directed against several thyroid- specific
antigens
- ewhen antibodies attach to antigen an inflammatory response is initiated
and the disease progresses to hypothyroidism
- Autoantibodies of disease:
- eanti-thyroglobulin (antiTg)
- ¸Antibodies against precursors of the thyroid hormones (thyroglobulins)
- eanti-thyroid peroxidase (anti-TPO)
- ¸also called Aanti-microsomal antibodies@
- ¸directed against thyroid peroxidase antigen
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- Other diseases with anti-Tg and anti-TPO present:
- ehyperthyroidism
- ethyroid tumors
- epernicious anemia - lack of intrinsic factor leads to vitamin B12
deficiency
- elupus erythematosus
- esome healthy individuals may test positive
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Notes
