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- Systemic Lupus Erythematosus
- OSF - 15
- Page 284
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- Mechanism of disease:
- eautoimmune disorder in which there is a non-organ specific
hyperactivity of the immune system
- ethese autoantibodies react with a variety of tissue antigens causing
ag-ab complexes to be formed
- ewhen ag-ab complexes are deposited on tissues it results in destruction
of that tissue
- Autoantibodies of disease:
- eantibodies are polyclonal
- ¸Antibodies to native DNA (anti-DNA) or also called double-stranded DNA
(dsDNA)
- ¸Antibodies to Smith antigen (anti-Sm
- ¸Antibodies are of the IgG and IgM class
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- Causes of disease:
- emay have viral origin
- ¸when viral stimulation of host DNA leads to production of anti-DNA
antibodies
- emay have genetic link:
- ¸HLA-DR2 - anti-dsDNA formed
- ¸HLA-DR3 - anti-SS-A and anti-SS-B formed
- ¸HLA-DR4 & HLA-DR5 - anti-Sm & anti-RNP formed
- Clinical findings:
- earthritis
- eskin rashes
- enephritis
- epulmonary disorders
- ecardiac disorders
- eoptical disorders
- eG.I. disorders
- eCNS disorders
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- Immunologic testing:
- epatients have elevated " and ( globulins
- epatients have decreased levels of albumins and complement proteins C3
and C4
- epatients have high titers of anti-Sm and anti-dsDNA
- epatients display nephrotic disorders due to ag-ab complexes being
deposited on basement membranes of glomerulus
- epatients display skin rashes due to ag-ab complexes being deposited on
dermal-epithelial junctions
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Notes
