SLE - 2
Mechanism of
disease:
eautoimmune disorder in which there is a non-organ
specific hyperactivity of the immune system
ethese autoantibodies react with a variety of tissue
antigens causing ag-ab complexes to be formed
ewhen ag-ab complexes are deposited on tissues it
results in destruction of that tissue
Autoantibodies
of disease:
eantibodies are polyclonal
Antibodies to native DNA (anti-DNA) or also called
double-stranded DNA (dsDNA)
Antibodies to Smith antigen (anti-Sm
Antibodies are of the IgG and IgM class
