SLE - 3
•Causes of disease:
•emay have viral origin
•when viral stimulation of host DNA leads to production of anti-DNA antibodies
•emay have genetic link:
•HLA-DR2 - anti-dsDNA formed
•HLA-DR3 - anti-SS-A and anti-SS-B formed
•HLA-DR4 & HLA-DR5 - anti-Sm & anti-RNP formed
•Clinical findings:
•earthritis
•eskin rashes
•enephritis
•epulmonary disorders
•ecardiac disorders
•eoptical disorders
•eG.I. disorders
•eCNS disorders