Testing for AIDS - 3
•Clinical course of HIV infection:
•ePrimary HIV infection
•eClinical latency
•eClinical AIDS
•Žhigh levels of HIV-1 detected in peripheral mononuclear cells and plasma
•Žanti-HIV-1 antibodies appear in plasma
•Žlevels of HIV-1 viral load desreases
•Ždiffers from individual to individual
•Žmay be rapid transition to clinical AIDS
•Žmay be 10 years or more for transition to clinical AIDS
•Žviral replication occurs in lymphoid tissues
•Žsmall amount of HIV-1 in peripheral blood
•Žproduction of HIV-1 = destruction of HIV-1