Inflammation - 5
Types of
inflammatory reactions: - continued
eAntibody-Mediated Inflammation - type I
hypersensitivity
ŽMechanisms of response:
IgE produced in response to initial stimulation of
immune system
IgE binds to IgE (Fc) receptors on mast cells/basophils
("sensitization")
when allergen (antigen) binds with more than two IgE
molecules on mast cell/basophil it causes cell to release granular
contents ("degranulation")
granular mediators released
ŽMediator induced changes that take place:
infiltration by cells
erythema, heat, & itching
