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1
One Step Further
  • Hepatitis B Vaccine
  • OSF - 2
  • Page 28
2
HBV - 2
  • History:
  • 1982 -first vaccine made available for use
  • purified suspension of inactivated HBV surface antigens
  • antigen obtained from chronic HBsAg carriers
  • Now -vaccine made from recombinant HBV antigen
  • Indications for vaccination against HBV:
  • ePre-exposure
  • ePost-exposure
  • ePerinatal exposure
  • Žhealth care professionals
  • Žthose at increased risk for exposure to HBV
  • Žindividuals who have been exposed to body fluids of patient who has tested positive for HBV
  • Žif mother tests positive for HBsAg at delivery, the newborn is treated same as post-exposure patient
3
HBV - 3
  • Vaccination/ L protocol:
  • ePre-exposure
  • Ž2 doses given 1 month apart
  • Ž3rd dose given after 6 months
  • ePost-exposure
  • Ždose administered within 24 hrs of exposure
  • Žbooster given 1 month post-exposure
  • ŽHBV immunoglobulin shot given (Ig=s to HBsAg)
  • Žstandard immunoglobulin shot given (Ab=s from immunized individuals)
4
HBV - 4
  • Laboratory Testing:
  • eImmune status confirmed by:
  • ŽPre-vaccination testing:
  • ŽPost-vaccination testing:
  • HBc positive
  • HBs positve
  • indicates current infection
  • HBc negative
  • HBs positve
  • confirms sero-conversion
5
HBV vaccine - 5