Tumor Markers - 12
•Gene/chromosome markers:
•eThere are a couple of markers that are used in diagnosis:
•Žp53 gene:
•mutated form seen in:
•hcolorectal cancer
•ŽPh1 chromosome
•also called the Philadelphia chromosome
•mutated form of chromosome is a translocation from chromosome 22 to chromosome 9 (t9,22)
•h85% of CML (chronic myelogenous leukemia) patients have this chromosome