Complement Activation - 2
•Two enzymatic pathways available:
•eClassical pathway
•eAlternative pathway
•Žfirst one discovered
•Žactivated by immune complexes
•Žactivated primarily by polysaccharide structures
•microbial cell walls is an example
•Two enzymatic pathways join at:
•eClevage of C5 which results in:
•Žformation of the Membrane Attack Complex (MAC)
•this results in lysis of cell