Graft-vs-Host Reaction - 6
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Mechanism:
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e
not well understood
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e
Natural killer cells (NK) act as effector cells
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e
belief is that IL-2 activates NK cells to become
lymphokine-activated killer cells (LAK)
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e
NK cells are seen attached to dying epithelial cells
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e
LAK cells are not MHC-restricted and are able to lyse
host cells