Immunologic
Tolerance - 2
1.Tolerance to Self-antigens - continued
L
B-lymphocytes
Nmature in
bone marrow
Nlack of THelper cell stimulation
Nthose that
react with self-antigens are eliminated by clonal abortion
Ncan be
induced to nonreactivity creating a state of anergy (unresponsiveness).
2.Tolerance
generated during an immune response
L Four
mechanisms that induce tolerance
Nclonal
exhaustion
Nanti-idiotype
antibodies
Nfeedback
inhibition
NTSuppressor cells
