Immunologic Tolerance - 3
•2.Tolerance generated during an immune response - continued
•L Four mechanisms that induce tolerance
•Nclonal exhaustion
•Nanti-idiotype antibodies
•Nfeedback inhibition
•NTSuppressor cells
•alymphocyte depletion due to:
•Uvigorous immune response
•Urepeated antigenic stimulation
•aantibodies formed against idiotypes can block sites of antigen attachment
•amolecules produced during immune response may block lymphocyte activation
•acytokine inhibition