Vaccine Design - 4
•
Live Viral vector vaccines:
•
e
Uses a live recombinant viral vector (carrier)
•
e
Gene that codes for the desired antigenic detrminants
(epitopes) are inserted into a non-pathogenic virus
•
e
Altered virus is then used as the vaccine
•
e
Applications under investigation include:
•
Ž
HIV
•
Ž
HBV
•
Ž
Herpes simplex vaccines
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