Adjuvants
Definition:
substances that non-specifically enhances an immune response
Mechanism of
action:
˜increases
size of antigenic molecule
˜prolongs the
retention of antigen
˜stimulates
macrophages and/or lymphocytes
Types of
adjuvants
˜Freund=s complete adjuvant
˜Freund=s incomplete adjuvant
˜Most common
one used in humans is:
ˆkilled
mycobacterium in H2O-oil
emulsion
ˆantigen + H2O + oil + emulsifying
agent
ˆantigen +
aluminum hydroxide (alum)
