Factors
Determining Immunogenicity - 1
Factors that determine an antigens
immunogenicity are: (continued)
˜Genetic
composition of host
˜Genetic
dissimilarity
˜Accessibility
˜Size of
antigenic molecule
ˆMHC gene
makeup
ˆantigen must
be recognized as being foreign
ˆthe greater
the phylogenetic distance the greater the antigenicity
ˆantigenic
epitopes must be available to immune system
ˆ> 10,000
molecular weight to be immunogenic
ˆmacromolecules
(>100,000) are potent immunogens
