Tumor
Markers - 2
Definition:
Tumor markers
are expressions of mutated genes, viral genes, or abnormal expressions of normal
host genes resulting
in the production of a specific protein.
First tumor
marker identified was:
eBence-Jones
protein
Žconsists of
light chains of immunoglobulins
Žproduced by
transformed B lymphocytes
Ž80% of
individuals who have multiple myeloma produce
these proteins
Ž20% of
pateints with Chronic Lymphocytic Leukemia (CLL) also form these proteins
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