Cytokines - 1
•Definition:
•Cytokines are a group of proteins that are produced by different cell populations and affect different target cells.
•Three functional groups of cytokines:
•eMediators and regulators of non-specific immune responses.
•Cytokine
•Produced by
•Target cell
• effects            
•IL-1
•IL-12
•TNF"
•IFN-(
•macrophages
•T-cells & B-cells
•stimulate cell division
•all APC=s
•Th1 and NK cells
•enhances other IL=s
•macrophages
•tumors
•inflammatory mediator
•T8+, NK, Th1
•NK cells
•cell activation
•Cytokines