Cytokines - 3
•Three functional groups of cytokines: cont=d
•eRegulators of hematopoiesis.
•Cytokine
•Produced by
•Target cell
• effects            
•IL-3
•IL-7
•GM-CSF
•M-CSF
•T-cells
•stem cells
•growth & differentiation of blood cells
•Stroma cells
•lymphocytes
•generate pre-T & pre-B cells
•macrophages
•myeloid stem
•growth & differentiation of myeloid line
•fibroblasts, macrophages
•monocytes
•stimulate production of monocytes & macrophages
•Cytokines