Cytokine - TNF-
a
•
macrophages
•
TNF-
"
•
All cells with TNF receptors
•
increased cytotoxicity and
antiviral activity
•
increased fibroblasts and
thymocytes production
•
stimulates IL-1, IL-6,
CD11b/CD18, & MHC-II
•
inflammatory mediator
•
regulates growth of normal
cells
•
induces weight loss
•
Cytokines