Cytokine - TNF-a
•macrophages
•TNF-"
•All cells with TNF receptors
•increased cytotoxicity and antiviral activity
•increased fibroblasts and thymocytes production
•stimulates IL-1, IL-6, CD11b/CD18, & MHC-II
•inflammatory mediator
•regulates growth of normal cells
•induces weight loss
•Cytokines