Function
of Complement
Functions of complement:
eBiological
effects
Ubacterial
opsonization
mC3b binds to
bacterial C3b receptor
Uchemotaxis
mC5a released
during inflammatory response acts as an attractant for:
-neutrophils
-macrophages
eCell lysis
Uantibodies
bind to cell surface
Ucomplement
activated via classical pathway
Umembrane
attack complex (MAC) formed
Ucell
destroyed via osmotic inbalance with H2O entering cell
Cytokines