Classic Pathway Activation
•ethe sequence of activation is:
•Immune complex
•\
•C1q of C1 complex
•\
•C4
•-
•C4a
•\
•C4b
•\
•C2
•-
•C2a
•\
•C2b
•C4b
•\
•C2b
•-
•C3 convertase
•C3 convertase
•\
•C3
•-
•C3b
•C3b
•\
•C3 convertase
•-
•C5 convertase
•C5 convertase
•\
•C5
•-
•C5b
•C5b
•\
•C6
•\
•C7
•\
•C8
•\
•C9
•MAC
•cell lysis
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