Alternative Pathway Activation
•ethe sequence of activation is:
•C3
•-
•C3b
•(C3b is found normally in the blood due to hydrolysis of C3)
•C3b
•-
•binds to microbial surface
•C3b
•\
•Factor D
•\
•Factor B
•-
•C3 convertase
•C3 convertase
•\
•C3
•-
•C3b
•C3b
•\
•C3 convertase
•-
•C5 convertase
•C5 convertase
•\
•C5
•-
•C5b
•C5b
•\
•C6
•\
•\
•\
•C7
•C8
•C9
•MAC
•cell lysis
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