Role of Lymphocytes - 3
•B-cell and T-cell interaction - continued
•B-cell
•antigen on MHC II
•Thelper (CD4+)
•TCR = CD3
•1.TCR on CD4+ cell recognizes antigen on MHC II of B-cell
•2.CD4+ cell secretes cytokines that cause B-cell to proliferate, differentiate, and secrete antigen specific antibodies
•UIL-2
•UIL-4
•IL-2 + IL-4
•3.the interaction of CD40 on B-cell with gp39 on CD4+ cell causes B- cell proliferation
•gp39
•CD40