B-Lymph Development -2
•Characteristics of Stages in B lymphocyte development: cont=d
•eImmature B lymphocytes
•Uexpress complete IgM on surface
•Uare not activated by antigens
•Ucontact with self-antigens may result in:
•-B-cell death
•-tolerance
•eMature B lymphocyte
•Ufound only in blood and lymphoid tissue
•Uexpress surface IgD and IgM
•Uboth surface immunoglobulins express same antigen specificity