General
Features of Transplantation - 1
eTissue (allograft) transplanted between
allogeneic (genetically non- identical) individuals will usually trigger an immune response.
eThe immune response may be specific
(cell-mediated or humoral) or nonspecific.
eGraft rejection occurs when the class I and
class II MHC molecules of the donor tissue do not Amatch@ those of the recipient.
eThe severity of rejection may be limited in
two ways:
1.by suppressing the recipient=s immune system
2.by testing for MHC compatibility
(histocompatibility) prior
to transplantation
eTissue grafted between identical twins
(syngeneic) does not result in rejection.
