Antibody-Dependent Cytotoxicity Complement Mediated
-host B-cells are activated by:
]IL-2, IL-4,
& IL-5 from antigen activated THelper-cells
-activated host B-cells then transform into
plasma cells
-plasma cells produce specific anti-graft
antibodies
-antibodies bind with HLA molecules of same
specificity and
complement is activated
-complement then lyses endothelial cells of
graft
-C3a & C5a from complement activation act
in inflammatory
reaction
