Antibody-Dependent Cytotoxicity
 Cell Mediated
•-host B-cells are activated by:
•]IL-2, IL-4, & IL-5 from antigen activated THelper-cells
•-activated host B-cells then transform into plasma cells
•-plasma cells produce specific anti-graft antibodies
•-antibodies bind with HLA molecules of same specificity
•-Natural killer (NK) cells bind to Fc portion of antibody
•-graft tissue is lysed