Immunosuppressive Drugs - Cytotoxic
•2.Cytotoxic drugs:
•-cyclophosphamide:
•-azathioprine
•drug of choice
•-methotrexate
•-chlorambucil
•]suppress proliferation of cells
•3.Cyclosprine drugs:
•-cyclosporine A
•]most important immunosuppressive drug used
•]selectively impairs CD4 cells production of IL-2
•]thus suppresses CD8 cell production
•]is not cytotoxic