Type II – Antibody-Dependent Cytotoxic
Description:
an immune
response that occurs when antibody (IgM or IgG) binds with cell surface antigen and
activate complement which lyse cells and the C3a and C5a attract macrophages, neutrophils, and basophils into area or NK cells lyse antibody-coated cells.
Mechanism of
tissue damage:
Uantigen
causes antibody to be produced
Uantibody
produced attached to antigen on target cell
UAb-Ag complex
may activate complement which lysis target cell via MAC attack
and/or
UAb-Ag complex
activates NK cell or TCytotoxic cells
which lysis
target cell
