Type
II – Blood Transfusion Reaction
Uthe reaction occurs when:
]incompatible antigens on donor red blood
cells are infused
into recipient
]recipient=s immune system has produced antibodies against antigens from a previous exposure
Uthe reaction=s features :
]previously produced antibodies form Ab/Ag
complexes on RBC=s surface
]these complexes activate complement via
classical pathway
]RBC=s
destroyed via MAC intravascularly
