Type II – Hemolytic Disease of Newborn
Uthe reaction occurs when:
]IgG
antibodies from mother cross placental barrier and attack red cells of fetus
]mother must
have been exposed to red cell antigens prior to pregnancy (previous pregnancy or
transfusion)
]the
incompatible antigens on fetal red cells are inherited from father
Uthe reaction=s features :
]Ab/Ag
complexes are formed on fetal red cells
]fetal red
cells are destroyed
