Mechanism of Self-Tolerance
•Uinvolves the T lymphocyte populations
•UPre-T lymphocytes with a potential to react with self-antigens are eliminated in the thymus gland
•Examples of Self-antigens involved in autoimmune disorders include:
•Ucell-surface receptors
•UErythrocyte surface proteins
•UBasement membranes of glomeruli
•UHormone receptors
•UNucleoproteins