Organ-Specific Autoimmune Disorders
The
immune response is directed primarily against antigens in or on a specific organ
Organ
involved
Antigen
targeted
Disease
Clinical
features
Adrenal gland
Adrenal cortex
Addison=s
Hypoadrenalism
Thyroid gland
TSH receptors
Grave=s
Hyperthyroidism
Thyroid cells
Hashimoto=s
Hypothyroidism
Skeletal or
heart Muscle
Acetylcholine receptors
Myasthenia
gravis
Muscle weakness
Kidney
Glomerular
basement membrane
Goodpasture=s
Glomerulonephritis
Pancreas
Islets of
Langerhan
Diabetes
mellitus type I
Insulin-dependent
hyperglycemia
CNS
myelin
Multiple
sclerosis (MS)
neurologic dysfunction