Tissue
Injury – Autoimmune Diseases
Mechanism responsible for tissue injury
include:
UAntibody-mediated
cytotoxicity
eIgG or IgM
type antibodies
eAttach to
antigen and causes cytolysis as in type II hypersensitivity reactions
UImmune
complex deposition
eAntibody-Antigen
complex forms
eNormally
removed by phagocytes
eIf not
removed they are deposited on various tissues as in Type III hypersensitivity reactions
UCell-mediated
cytotoxicity
eWhen T
cells fail to recognize self-antigens they can begin destroying host cells via type IV hypersensitivity reactions
