Histocompatibility
in Transplantation
Complete tissue compatibility:
UOnly if
between identical twins
UHave same
histocompatibility (HLA) antigens
Graft rejection
occurs:
Ubecause of
foreign HLA antigens
Uthe greater
the mismatch of HLA antigens the higher the risk of rejection
Pre-transplantation
testing:
UTissue
typing:
UCrossmatch:
UHLA antibody
screening/identification:
eidentification
of HLA class I and HLA class II antigens
edetects the
presence of antibodies (anti-HLA) in patient that react with HLA antigens of donor
edetects the
presence of antibodies (anti-HLA) in patient and identifies the type of antibody.
