Hyperactive Immune System
•Hyperactivity of immune system results from:
•UInappropriate response to self-antigens (autoimmune disorders)
•UHeightened immune response to harmless antigens (allergies)
•UAbnormality of antibody-producing cells (B or plasma cells)
•Autoimmune diseases:
•UOccurs when there is a loss of self-tolerance and antibodies produced against self-antigens
•UClassifications of autoimmune disorders:
•eorgan-specific
•eSystemic
•_autoantibodies show specificity for antigens expressed on a particular organ
•_autoantibodies directed against various cellular components and react with a variety of organs