Systemic Autoantibodies
•Disease
•Autoantibodies to which structures                     
•Lupus erythematosus
•ds-DNA, Sm, nRNP
•ds-DNA =   double-stranded DNA
•Sm =   Smith antigen
•nRNP =   nuclear ribonucleoprotein
•Rheumatic fever
•Pernicious anemia
•intrinsic factor, parietal cells, intestinal receptors
•Autoimmune hemolytic anemia
•variety of red cell antigens
•Scleroderma
•Scl-70, centomere
•Scl-70 =   scleroderma antigen