Binding Forces
•eforces that bind an antigen (epitope) and antibody (idiotype) are relatively weak and results in complexes that can be broken apart relatively easily:
•UIonic attraction:
•oposite charged portions of the molecules are attracted to each other
•UHydrogen bonds:
•bonds that form between negatively charged atoms and positively charged atoms of polar molecules (COO- and H+)
•UHydrophobic bonds:(most important one)
•bonds that form between nonpolar molecules causing elimination of water molecules
•UVan der Waals forces:
•weak forces of attraction which are dependent upon interaction between external electron clouds