Multiple
Sclerosis - 2
Mechanism of Disease:
ecause is unknown
ebelief is that genetic and environmental
factors play a role
ŽGenetic factors:
these two HLA antigens are present in patient=s with MS
~DRw15
~DQw6
ŽEnvironmental factors:
~inflammatory immune response to bacterial and viral infections may trigger autoimmune response seen in MS patients
e80% of MS patients have IgG produced in CSF that is directed against basic protein of myelin
sheath. This results in demyelination and formation of
lesions called Aplaques@ in white matter of brain and spinal cord
edemyelination may cause:
visual distrubances
lack of locomotor coordination
