Multiple
Sclerosis - 3
Laboratory findings:
eit is important to determine source of IgG
in CSF
Žis it produced in the spinal cord
Žis it produced elsewhere and has crossed the
blood- brain
barrier
etwo assays used to determine origin of IgG
in CSF:
Žoligoclonal banding technique:
~protein electrophoresis of CSF shows
multiple bands in the
( region
~protein electrophoresis of serum shows multiple bands in the ( region
~if isoelectric focusing used:
qCSF shows band pattern in ( region
qserum shows no band
pattern in ( region
