Mechanism of disease:
ewoman has
been exposed to red blood cell antigens which are not found on
her own red blood cells and her immune system has responded
by producing antigen-specific antibodies
ethese maternal antigen-specific IgG antibodies cross the placental
barrier and attach to fetal red cells having the antigen on
them
efetal red cells are then lyzed and resulting bilirubin is handled by
maternal liver
eonce the baby is delivered the baby=s liver must
handle the bilirubin
emost frequent
antigen-antibodies involved in HDN are:
A
antigen/anti-A antibodies
B
antigen/anti-B antibodies
D
antigen/anti-D antibodies
other Rh
antigens/anti-Rh antibodies
ABO HDN
Rh HDN
HDN - 2
