Hashimoto=s Thyroiditis - 2
Mechanism of disease:
eautoimmune disorder seen most often in women
and is leading cause
of thyroiditis (inflammation of thyroid gland).
ethese autoantibodies are directed against
several thyroid- specific
antigens
ewhen antibodies attach to antigen an
inflammatory response
is initiated and the disease progresses to hypothyroidism
Autoantibodies of disease:
eanti-thyroglobulin (antiTg)
Antibodies against precursors of the thyroid
hormones
(thyroglobulins)
eanti-thyroid peroxidase (anti-TPO)
also called Aanti-microsomal antibodies@
directed against thyroid peroxidase antigen
