SLE
- 2
Mechanism of disease:
eautoimmune disorder in which there is a
non-organ specific hyperactivity
of the immune system
ethese autoantibodies react with a variety of
tissue antigens
causing ag-ab complexes to be formed
ewhen ag-ab complexes are deposited on
tissues it results in destruction
of that tissue
Autoantibodies of disease:
eantibodies are polyclonal
Antibodies to native DNA (anti-DNA) or also called double-stranded DNA (dsDNA)
Antibodies to Smith antigen (anti-Sm
Antibodies are of the IgG and IgM class
